They left the Cape in 1835, and reached the Soutpansberg (staying until 23 August 1837). Trichardt's group then left for Lourenço Marques. The trek crossed the border of the present day Kruger National Park on the 6 March 1838, at Tshokwane.
They trekked through the Malaria and Nagana (sleeping sickness) infested area, and the remnants of the party reached Lourenço Marques (Delagoa Bay) on 13 April 1838. Louis Trichardt and most of his followers died during the journey and a memorial was set up which commemorates him.
In 1843, Andries Potgieter attempted to find a more southerly route from Pretoria to Lourenço Marques, but the one that his party took turned out to be almost impossible to negotiate. The trek came to a halt at the edge of the Drakensberg Escarpment from which there was no possible way to descend. A scouting party was sent out, which consequently discovered an animal track that permitted access to the Lowveld.
Evidence still exists of a route from Lydenburg to Delagoa Bay, which was established by the Afrikaners to gain access to the sea for trade purposes, in order that they did not have to be dependent on British ports.
Although the Voortrekkers were establishing themselves in the area, others, with an eye on trading and profits, have left their mark, not least of whom was João Albasini.
Jakob Louis van Wyk first introduced the idea of creating a game reserve to the Volksraad (the old term used for parliament) of the old South African republic in 1895. After many discussions about how to protect the wildlife of the Lowveld, the president of the Transvaal Republic, Paul Kruger, proclaimed a Government Wildlife Park in 1898.
The name of the park later changed to Sabi Game Reserve, with James Stevenson Hamilton serving as the first warden. During Hamilton's 44 years as warden of Sabi, the reserve expanded and the current name, Kruger National Park, came into existence in 1926. The park's first motorists entered the wildlife-rich area in 1927.
After retiring, Hamilton was replaced by Colonel J. A. B. Sandenbergh, a former employee of the South African Air Force. Under his term, the park's boundaries were fenced off from other countries. The operation that had begun in 1959 aimed to prevent the spread of diseases among wildlife and to regulate border control to curb poaching.